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Symbol Name ID |
Cul4b
cullin 4B MGI:1919834 |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Ventriculomegaly |
Polymicrogyria |
Simplified gyral pattern |
Cortical dysplasia |
Abnormal cerebral white matter morphology |
Hypoplasia of the corpus callosum |
Cerebellar vermis atrophy |
Gait ataxia |
Tremor |
EEG abnormality |
Abnormality of speech or vocalization |
Absent speech |
Delayed speech and language development |
Emotional lability |
Aggressive behavior |
Hyperactivity |
Intellectual disability |
Intellectual disability, moderate |
Intellectual disability, severe |
Broad-based gait |
Motor delay |
Seizure |
| Disease(s) Associated with CUL4B | |||||||||||||||||||||||
| syndromic X-linked intellectual disability Cabezas type |
| Mouse Phenotypes | increased susceptibility to pharmacologically induced seizures |
abnormal dendrite morphology |
abnormal dendritic spine morphology |
decreased neuron number |
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| Availability | Mouse Genotype | ||||
| Cul4btm1Swl/Y Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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